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Friday, September 20, 2013
Disruption of cells is a process whereby biological molecules inside of a cell are released. The disruption of cells  is necessary for methods of cloning or culturing, and the process allows individuals to study the molecules inside of the cell. All molecules can be studied, with the exception of excreted molecules, which are living cells. In order to  disrupt cells, the cell size can be as small as a few milliliters or milligrams. When disrupting cells it is important to be extremely careful, to minimize losing a cell, and to avoid accidental cross contamination. A disruptor can disrupt 192 cells at once. Some cells that are easy to disrupt and others are more difficult; brain tissue is an easy cell to disrupt, while yeast cells can be more difficult.

Branson cell disruptors have been the benchmark when it comes to experiments of this type in the laboratory, having been used in research studies for over 60 years. They are referred to as sonifiers; they are tools used in the the laboratory to apply high ultrasonic energy for chemical and biological tasks such as cell disruption. Branson Cell Disruptors come in several different models, with varying wattage and different types of horns; the model chosen would depend upon its intended purpose.

An example would be the Branson Sonifier 400W Analog Cell Disruptor with ¾” Solid Horn, S-450A. This model uses traditional technology to help produce reliable results. This analog system has an auto tune memory, adjustable power for output which minimizes heat for sensitive samples, a timer and an output meter which helps process power. This system comes with a two year manufacturer warranty. Accessories made for these units include Branson Ultrasonic Cleaning Solutions and replacement parts for maintaining the system. This will make the Branson machine run better and longer. Cell disruptors are available in analog or digital models.

When it comes to the digital models of Branson Cell Disruptors, each one has a consistent power supply, a probe, and a converter, along with the benefits enabled by newer digital technology. In the digital models, cell disruption is done by creating ultrasonic vibrations. The converter on this machine will transmit the vibrations through a mechanical probe, referred to as a “horn”. There are two basic models of Digital Cell Disruptors; Digital 250 and Digital 450, with variations depending upon the size of horn  provided with the unit and the wattage.
When it comes to analog cell disrupters, each one of the models come with a power supply, mechanical probe (horn), along with a converter. In the analog machine the cavitations are created through ultrasonic vibrations. The converter will transmit the vibration through the probe, which will be applied to the samples indirectly or directly.

by: getMedOnline


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